Absence of BRAF mutation in pediatric and adolescent germ cell tumors indicate biological differences to adult tumors
| Autor: | Christian Vokuhl, Gabriele Calaminus, Monika Szczepanowski, Ivo Leuschner, Jochen Haag, Neus Masqué-Soler, Wolfram Klapper |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Oncology
medicine.medical_specialty Mutation endocrine system diseases business.industry Microsatellite instability Hematology medicine.disease_cause MLH1 medicine.disease digestive system diseases MSH6 Internal medicine Pediatrics Perinatology and Child Health medicine Cancer research Germ cell tumors KRAS business neoplasms Gene V600E |
| Zdroj: | Pediatric Blood & Cancer. 59:732-735 |
| ISSN: | 1545-5009 |
| Popis: | The V600E mutation of the BRAF gene has been reported to be associated with poor prognosis of germ cell tumors in adult patients. We analyzed the mutational status of the BRAF and KRAS gene as well as MLH1 and MSH6 expression as surrogate markers for microsatellite instability in 70 pediatric germ cell tumors. Neither BRAF and KRAS mutations nor loss of MLH1 and MSH6 expression were found. Our data provide further evidence for patient age related biological differences in germ cell tumors and demonstrate that prognostic biomarkers cannot necessarily be transferred from one age group to the other. Pediatr Blood Cancer 2012;59:732–735. © 2011 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text