Induction of microglial nitric oxide synthesis by very low density lipoprotein
| Autor: | March D. Ard, Pamarthi F. Mohan |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
Very low-density lipoprotein Microglia Superoxide Neurotoxicity Biology medicine.disease Nitric oxide Cellular and Molecular Neuroscience chemistry.chemical_compound medicine.anatomical_structure Endocrinology Neurology Biochemistry chemistry Internal medicine medicine Neuroglia lipids (amino acids peptides and proteins) Incubation Lipoprotein |
| Zdroj: | Glia. 17:259-262 |
| ISSN: | 1098-1136 0894-1491 |
| DOI: | 10.1002/(sici)1098-1136(199607)17:3<259::aid-glia8>3.0.co;2-w |
| Popis: | The effect of lipoproteins on adult rat CNS microglial nitric oxide (NO) production was studied. Incubation of cultured microglia with very low density lipoprotein (VLDL) for 48 h induced a 13-fold increase in NO production, compared with control. However, the induction of NO was negated when cells were incubated with VLDL and the NO synthase inhibitor N-methyl-L-arginine. High and low density lipoproteins (HDL and LDL) did not significantly induce NO synthesis in microglial cells. These results suggest that the lipoprotein environment in the brain can influence neurotoxic activity of microglia via production of NO. |
| Databáze: | OpenAIRE |
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