Stability of Two Extemporaneously Prepared Oral Metoprolol and Carvedilol Liquids
| Autor: | E. Kurt Dolence, Weeranuj Yamreudeewong, Deborah Pahl |
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| Rok vydání: | 2006 |
| Předmět: | |
| Zdroj: | Hospital Pharmacy. 41:254-259 |
| ISSN: | 1945-1253 0018-5787 |
| DOI: | 10.1310/hpj4103-254 |
| Popis: | The stability of metoprolol and carvedilol in extemporaneously prepared oral liquids was studied. An aqueous liquid formulation of each drug was prepared by reconstituting the powder from triturated tablets with a mixture of deionized water and 70% sorbitol solution. The expected metoprolol concentration was 1.25 mg/mL and for carvedilol was 0.625 mg/mL. Polyethylene terephthalate (PET) plastic bottles containing metoprolol and carvedilol liquids were stored at ambient room temperature (22° to 26°C, and in the refrigerator (4° to 8C). After storage periods of 1, 2, 4, and 8 weeks, these samples were analyzed in triplicate for the respective drug concentrations by high-performance liquid chromatography (HPLC). The concentration of each drug was found to be within the acceptable limit (± 10% of the initial concentration) in all test samples, which indicated that metoprolol and carvedilol liquids were stable at room temperature and refrigerated for up to 8 weeks. However, there were signs of possible decomposition in metoprolol oral liquid after 8 weeks of storage at room temperature. Additionally, our study findings revealed that there was no microbial growth in either drug liquid after a refrigerated storage period of 2 weeks. Hosp Pharm — 2006;41:254-259 |
| Databáze: | OpenAIRE |
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