Nephrotoxicity of contrast media in persons over the age of 60

Autor: D Koutsikos, I Konstadinidou, A. Kapetanaki, Basil Agroyannis, Lambros Vlachos, Helen Tzanatos
Rok vydání: 1993
Předmět:
Zdroj: Geriatric Nephrology and Urology. 3:127-131
ISSN: 1573-7306
0924-8455
DOI: 10.1007/bf01508805
Popis: The nephrotoxicity potential and differences of three different contrast media, a high osmolar ionic (Diatrizoate), a low osmolar ionic (Ioxaglate) and a low osmolar non-ionic (Iohexol) after intravenous administration in 84 non-diabetic patients with normal renal function (26 female, 58 male) submitted to digital vascular imaging, were investigated. Forty-five patients (12 female, 33 male) were over 60 years (62–78, mean 66) while 39 patients (14 female, 25 male) less than 60 (36–57, mean 46) years of age. The volume of contrast agent and iodine content were similar in all patients. Serum levels of creatinine, uric acid, β2-microglobulin, 24 hrs urine content of creatinine, uric acid, β2-microglobulin and proteins before and 24 hours after contrast medium administration were measured and clearances of creatinine, β2-microglobulin and uric acid were estimated. No statistical differences were detected in glomerular and tubular function following administration of contrast medium between the two age groups. Based on our results it can be concluded that, in non-diabetic patients with normal renal function over the age of 60 years, the use of low osmolality ionic or non-ionic contrast media will not decrease the nephrotoxicity risk after intravenous administration, and that the seven to ten times higher cost of the newer contrast media (Ioxaglate, Iohexol) should be taken under serious consideration when these agents are considered for use.
Databáze: OpenAIRE
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