Effects of the Interaction of Variants of the Serotonin Transporter and Brain-Derived Neurotrophic Factor on Platelet Serotonin Levels in Stroke Patients

Autor:	M. I. Faktor, Petrova Ea, Vera Golimbet, Brusov Os, Skvortsova Vi, Zlobina Gp, Savina Ma, Tatyana Lezheiko, Lavrushina Om
Rok vydání:	2011
Předmět:	Brain-derived neurotrophic factor medicine.medical_specialty biology General Neuroscience medicine.disease Endocrinology Neurotrophic factors Internal medicine Genotype medicine biology.protein Platelet Serotonin Allele Psychology Neuroscience Stroke Serotonin transporter
Zdroj:	Neuroscience and Behavioral Physiology. 41:554-557
ISSN:	1573-899X 0097-0549
DOI:	10.1007/s11055-011-9454-1
Popis:	Polymorphisms in two genes, i.e., the serotonin transporter and brain-derived neurotrophic factor, were studied in 47 patients with ischemic stroke. Platelet serotonin content was found to differ in carriers of different genetic variants. The lowest serotonin contents were found in patients with the LL*ValVal variant and the highest in those with the LL genotype and genotypes containing at least one copy of the Met allele. Genetic variants were not found to have any modulatory influences on the relationship between platelet serotonin content during the acute phase of stroke and the development of affective or anxiety disorders by the patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a81dea9b6cc5fa626d19e3a164b80b17 https://doi.org/10.1007/s11055-011-9454-1 Zobrazit plný text záznamu Full text from SpringerLink