MODULATION OF FILARIAL GLUTATHIONE-S-TRANSFERASE(S) ACTIVITY: A POSSIBILITY TOWARDS THE SYNTHESIS OF NEW CLASSES OF ANTIFILARIAL AGENTS

Autor:	Rolf D. Walter, Rumana Ahmad, Neetu Tewari, Arvind K. Srivastava, Ram Chandra Mishra, R.P. Tripathi
Rok vydání:	2004
Předmět:	biology Chemistry Stereochemistry Organic Chemistry Pharmacology toxicology Detoxification enzymes Glycopeptide chemistry.chemical_compound Glutathione S-transferase Biochemistry biology.protein Glycosyl General Pharmacology Toxicology and Pharmaceutics Inhibitory effect
Zdroj:	Medicinal Chemistry Research. 13:724-745
ISSN:	1554-8120 1054-2523
DOI:	10.1007/s00044-004-0113-8
Popis:	In a search towards the inhibitors/stimulators of filarial glutathione-S-transferase(s) (GST(s)), the major detoxification enzymes, a total of 335 compounds belonging to three major chemical classes were looked for their effect on soluble filarial GST(s). Among a total of 10 diglycosylated diaminoalkanes (DGDA), 4 showed more than 50% stimulatory effect, among 10 glycosylated hydroxamic acids, 2 showed more than 50% stimulatory effect and among 4 glycopeptides, 3 showed more than 50% stimulatory effect. Among a total of 38 glycosyl ureas, 2 showed more than 50% inhibitory effect. Among a total of 66 glycosyl ureas/ thioureas and glycopeptidyl ureas, 3 showed more than 50% stimulatory effect whereas 2 showed more than 50% inhibitory effect. Among a total of 59 C-nucleosides/ S-containing nucleosides, 24 showed more than 50% stimulatory effect.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a811ca7bb2dbc124e2f9ab326f2a3352 https://doi.org/10.1007/s00044-004-0113-8 Zobrazit plný text záznamu Full text from SpringerLink