Lung and oropharyngeal depositions of fenoterol hydrobromide delivered from the prototype III hand-held multidose Respimat nebuliser

Autor: S.P Newman, K.P Steed, L.J Towse, B Freund
Rok vydání: 1997
Předmět:
Zdroj: European Journal of Pharmaceutical Sciences. 5:55-61
ISSN: 0928-0987
DOI: 10.1016/s0928-0987(96)00016-4
Popis: A novel pocket-sized multidose nebuliser device (Respimat, Boehringer Ingelheim) has been developed for the delivery of asthma medications. The lung and oropharyngeal deposition patterns of an aqueous fenoterol formulation delivered from a prototype III Respimat equipped with two different nozzles (C11 and C16a) have been measured in 10 healthy volunteers using the technique of gamma scintigraphy. The results were compared with those obtained with the same dose (100 μg) fenoterol (Berotec 100, Boehringer Ingelheim) delivered via a pressurised metered dose inhaler (MDI). Mean (±S.D.) whole lung deposition from the Respimat C16a nozzle (31.1±10.3% of the metered dose) was significantly greater than that from either the Respimat C11 nozzle (14.2±5.5%) or the MDI (14.3±8.0%). Oropharyngeal deposition was significantly less for the Respimat C16a nozzle (mean 53.7%) than for both the Respimat C11 nozzle and the MDI (means 79.4 and 71.3% respectively). The Respimat could be a feasible alternative to MDIs and to powder inhalers for delivery of asthma medications.
Databáze: OpenAIRE
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