Dihalooxygenation of Alkynes and Alkynols: Preparation of 2,2-Dihaloketones and gem-Dihalolactols

Autor:	Charnsak Thongsornkleeb, Nattawadee Chaisan, Sureeporn Ruengsangtongkul, Jumreang Tummatorn, Somsak Ruchirawat
Rok vydání:	2022
Předmět:	Organic Chemistry
Zdroj:	Synlett. 33:1426-1430
ISSN:	1437-2096 0936-5214
DOI:	10.1055/a-1774-7077
Popis:	A mild and convenient method for the synthesis of 2,2-dihaloketones and gem-dihalolactols has been developed. For the synthesis of 2,2-dihaloketones, alkynes were employed as substrates to react with halogenating agents, Cl2 or ClBr, that were generated in situ from aqueous HCl and NCS or NBS, respectively. On the other hand, gem-dihalolactols could be prepared from alkynol substrates by using the same reaction conditions. This method could be applied to a broad range of substrates to give the corresponding products in low to good yields.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a7fff9f26d224ad576e51c58be3f1704 https://doi.org/10.1055/a-1774-7077 Zobrazit plný text záznamu