P68 – 3015: Autoimmune disorders are the common cause of non-purulent cerebrospinal fluid pleocytosis in children

Autor: R. Valkovicova, K. Paderova, Z. Liba
Rok vydání: 2015
Předmět:
Zdroj: European Journal of Paediatric Neurology. 19:S113
ISSN: 1090-3798
0006-4203
DOI: 10.1016/s1090-3798(15)30381-0
Popis: Objective White blood cell (WBC) counts in cerebrospinal fluid (CSF) are critical in the diagnoses of inflammatory neurological disorders. CSF are routinely tested for many different infectious agents. Nevertheless, the autoimmune etiology cannot be ignored. What are the common causes of pleocytosis in CSF in non-purulent cases and how frequent is the autoimmune etiology in our patients? Methods Retrospective evaluation of clinical and laboratory data of 174 patients who had pleocytosis in CSF (WBC Results Neuroborreliosis was a dominant etiology of pleocytosis in CSF and was responsible for 98 cases (medians: age 7 years, 100 WBC/ul): 73% had cranial nerves pathology, 23% meningitis and 4% radiculitis. Autoimmune disorder was diagnosed in 38 patients (medians: age 12 years, 10 WBC/ul): 58% had inflammatory process in the brain and spine (different types of encephalitis, cerebellitis etc.), 29% sclerosis multiplex and 13% affection of cranial nerves or polyradiculoneuritis. Enterovirus and tick-borne virus caused meningoencephalitis in 16 patients with pleocytosis (medians: age 12 years, 42 WBC/ul). The etiology of pleocytosis was not identified in 19 patients. Conclusion Autoimmune disorders were the second most common etiology of CSF pleocytosis in children. Autoimmune process was more likely responsible for brain and spine affections while the infectious inflammation preferentially affected meninges and cranial nerves. The pleocytosis was significantly more prominent in neuroinfection than in autoimmune disorders. The unknown etiology of pleocytosis still remained in 11% patients. Supported by “Foundation Neuron for Science Support” and the project for conceptual development of research organization 00064203.
Databáze: OpenAIRE
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