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Background: Platelets are a rich source of proteins and growth factors that are instrumental in the initiation and modulation of tissue repair. The clinical use of crude platelet preparations has been around for decades. However, the use of autologous platelet gel (APG) for the treatment of wounds has become familiar practice in only the past 10 years. Platelet gels have been associated with accelerated vascular ingrowth, increased fibroblastic proliferation, and accelerated collagen production.x3 Objective: The purpose of this study was to examine the effects of APG using a porcine wound healing model. Methods: Platelet rich plasma (PRP) was obtained using a fully automated, easy-to-use devise. APG was created from PRP and autologous thrombin. Deep partial thickness wounds were created on specific pathogen-free pigs. Wounds were either treated with APG and covered with a polyurethane dressing, were treated only with a polyurethane dressing, or were left untreated. Wounds were assessed for epithelization using a well-established salt-split technique. Results: Wounds treated with APG enhanced the rate of epithelization as compared to both polyurethane and untreated controls. Conclusions: This study shows that an autologous platelet rich gel can stimulate and enhance epithelization of deep partial thickness wounds. Additional preclinical and clinical studies that examine mechanisms of action are warranted. |
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