Iron-catalyzed Michael reactions revisited: a synthetically useful process for the preparation of tri-carbonyl compounds and chiral warfarin

Autor:	Li Li, Chungu Xia, Li-Wen Xu, Zhen-Yu Jiang, Yue-Hua Gao, Guoqiao Lai, Hua-Meng Yang
Rok vydání:	2010
Předmět:	chemistry.chemical_classification Ketone Chemistry education Organic Chemistry Enantioselective synthesis Biochemistry humanities Catalysis chemistry.chemical_compound Organocatalysis Drug Discovery Michael reaction Organic chemistry Amine gas treating Methylene Brønsted–Lowry acid–base theory
Zdroj:	Tetrahedron Letters. 51:3836-3839
ISSN:	0040-4039
Popis:	The LBAs (Lewis acid-assisted Bronsted acid catalysis) is proposed as possible mechanistic process in the simple FeCl3-catalyzed Michael reactions of chalcones with active methylene compounds in organic solvents. And iron salts were found to be effective promoters in the asymmetric Michael addition of 4-hydroxycoumarin to α,β-unsaturated ketone, which resulted in excellent yield and high level of enantioselectivity (up to 91% ee) in the presence of low catalytic amount of iron and simple chiral primary amine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a7f39feb0bb68a27d95b3cdc5a56b744 https://doi.org/10.1016/j.tetlet.2010.05.074 Zobrazit plný text záznamu Full Text from ScienceDirect