The synthesis of a C1-C8 lactone fragment of discodermolide

Autor:	Golec Julian M C, Stuart Donald Jones
Rok vydání:	1993
Předmět:	chemistry.chemical_classification Natural product Ozonolysis Stereochemistry Organic Chemistry Diol Enantioselective synthesis Discodermolide Biochemistry Aldehyde chemistry.chemical_compound chemistry Drug Discovery Aldol condensation Lactone
Zdroj:	Tetrahedron Letters. 34:8159-8162
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(00)61479-x
Popis:	The asymmetric synthesis of a fragment corresponding to the C 1 -C 8 region of the immunosuppressant dicodermolide is reported. A trihydroxylactone of defined absolute stereochemistry is also prepared. This compound is a potential reductive ozonolysis product of discodermolide and may aid the determination of the absolute stereochemistry of the natural product.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a7ed616850c2f1a0fe625c0e26d0ed7c https://doi.org/10.1016/s0040-4039(00)61479-x Zobrazit plný text záznamu