Aceton – Addendum: (Re)evaluierung des BAT-Wertes und eines BAR
| Autor: | Ochsmann, Elke, Schriever-Schwemmer, Gerlinde, Drexler, Hans, Hartwig, Andrea, MAK Commission |
|---|---|
| Jazyk: | němčina |
| Rok vydání: | 2022 |
| Předmět: |
biological tolerance value
biological reference value acetone BAT value Toxizität Urin 2-Propanon Biologischer Arbeitsstoff-Toleranz-Wert Hintergrundbelastung hazardous substance Biologischer Arbeitsstoff-Referenzwert developmental toxicity background exposure Pyroessigether Methylacetyl prenatal toxicity toxicity occupational exposure Gefahrstoff BAR fruchtschädigende Wirkung biomonitoring Ketopropan Arbeitsstoff Propan-2-on Entwicklungstoxizität Aceton Dimethylketon BAT-Wert |
| DOI: | 10.34865/bb6764d7_1ad |
| Popis: | In 2018, the German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re-evaluated acetone [67-64-1] and has derived a biological tolerance value (BAT value) and a biological reference value (BAR).In correlation to the maximum concentration at the workplace (MAK value) of 500 ml acetone/m³, a BAT value of 50 mg acetone/l urine was derived. Sampling time is at the end of exposure or the end of the shift. According to currently available information damage to the embryo or foetus cannot be excluded after exposure to acetone concentrations at the level of the MAK and BAT value (Pregnancy Risk Group B). The MAK value documentation indicates that based on the NOAEC (no observed adverse effect concentration) for developmental toxicity of 2200 ml/m³ no prenatal toxic effects of acetone are to be expected at about 200 ml/m³. The corresponding internal exposure of 20 mg acetone/l urine would be the prerequisite for an assignment to Pregnancy Risk Group C, which means that damage to the embryo or foetus is unlikely at this concentration. Taking the results of studies of occupationally non-exposed individuals with indications regarding the 95th percentile into consideration, a BAR of 2.5 mg acetone/l urine was derived. |
| Databáze: | OpenAIRE |
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