Transcutaneous auricular vagus nerve stimulation for the treatment of irritable bowel syndrome: a pilot, open-label study

Autor:	Sabine Roman, Aurélien Garros, François Mion, Henri Damon, Bruno Bonaz, Sonia Pellissier
Rok vydání:	2020
Předmět:	business.industry medicine.medical_treatment General Medicine medicine.disease 03 medical and health sciences 0302 clinical medicine Open label study Anesthesia medicine 030211 gastroenterology & hepatology business 030217 neurology & neurosurgery Irritable bowel syndrome Vagus nerve stimulation
Zdroj:	Bioelectronics in Medicine. 3:5-12
ISSN:	2059-1519 2059-1500
Popis:	Aim: Irritable bowel syndrome (IBS) is a frequent disease, associating chronic abdominal pain and abnormal bowel habits. The sympatho-vagal balance may be altered in IBS. We tested the effect of transcutaneous auricular stimulation of the left vagus nerve (taVNS) on symptoms and physiological and biological variables. Patients & methods: Twelve IBS women agreed to apply taVNS for 6 months. Evaluation was based on feasibility, symptoms, psychological questionnaires, fecal caprotectin, blood cytokines and bowel transit times. Results: Nine patients completed the trial: there was a significant improvement of symptoms at 3 and 6 months although none of the measured variables were modified by taVNS. Conclusion: The results suggest taVNS is feasible and may improve IBS symptoms. Randomized controlled studies are needed to confirm these preliminary results. ClinicalTrials.gov : NCT02420158.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a7e6b5e1fec84fb5654eb63057d07823 https://doi.org/10.2217/bem-2020-0004 Zobrazit plný text záznamu