Pork Adrenal-Cortex Extract: Effect upon Carbohydrate Metabolism and Work Capacity in Addison's Disease1
| Autor: | Cyril M. MacBRYDE, F. A. De La Balze |
|---|---|
| Rok vydání: | 1944 |
| Předmět: |
medicine.medical_specialty
business.industry Adrenal cortex Endocrinology Diabetes and Metabolism Biochemistry (medical) Clinical Biochemistry Muscular weakness Disease Hypoglycemia Carbohydrate metabolism medicine.disease Biochemistry chemistry.chemical_compound Endocrinology medicine.anatomical_structure chemistry Clinical evidence Corticosterone Adrenal cortex extract Internal medicine Medicine business |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 4:287-296 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem-4-7-287 |
| Popis: | EXTENSIVE experimental and clinical evidence indicates that the adrenal cortex plays a direct and positive role in the control of carbohydrate metabolism, but the mechanism of the control is not clear and many of the collected data are contradictory. No attempt will be made to review all of the pertinent literature, since this has been well done elsewhere (1). The purpose of this report is to emphasize the inadequacy of the present methods of treating Addison's disease, especially in regard to the deranged carbohydrate metabolism, and to describe studies with pork adrenal-cortex extract. This extract has for the first time given us a means of restoring the carbohydrate metabolism to normal. Among 28 patients with Addison's disease whom we have studied, the fasting bloodsugar level of 13 has been lower than average normal. In seven of these patients hypoglycemia has been severe enough to cause frequent symptoms and definite muscular weakness. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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