Beyond Supersecondary Structure: Physics-Based Sequence Alignment
| Autor: | S. Rackovsky |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification Computer science Sequence alignment Computational biology Physics based Protein structure prediction 01 natural sciences Amino acid 03 medical and health sciences 030104 developmental biology chemistry 0103 physical sciences Supersecondary structure Homology modeling 010306 general physics CASP Sequence (medicine) |
| Zdroj: | Methods in Molecular Biology ISBN: 9781493991600 |
| DOI: | 10.1007/978-1-4939-9161-7_18 |
| Popis: | Traditional approaches to sequence alignment are based on evolutionary ideas. As a result, they are prebiased toward results which are in accord with initial expectations. We present here a method of sequence alignment which is based entirely on the physical properties of the amino acids. This approach has no inherent bias, eliminates much of the computational complexity associated with methods currently in use, and has been shown to give good results for structures which were poorly predicted by traditional methods in recent CASP competitions and to identify sequence differences which correlate with structural and dynamic differences not detectable by traditional methods. |
| Databáze: | OpenAIRE |
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