ChemInform Abstract: Synthesis of the Louisianin Alkaloid Family via a 1,2,4-Triazine Inverse-Electron-Demand Diels-Alder Approach

Autor:	Steven A. Raw, Richard J. K. Taylor, Michael G. Edwards, Nicola Catozzi, Pierre Wasnaire
Rok vydání:	2010
Předmět:	chemistry.chemical_compound chemistry Stereochemistry Alkaloid Pyridine Diels alder Inverse General Medicine Louisianin B Triazine
Zdroj:	ChemInform. 41
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.201012180
Popis:	Isolated in 1995, the four members of the louisianin family (A, B, C and D) are simple pyridine and 2-pyridone alkaloids that display both antibacterial and anticancer activity. Herein we describe the synthesis of all four members of the louisianin family, from a conveniently prepared 1,2,4-triazine and via a common tetrasubstituted pyridine intermediate. This study includes the synthesis of louisianin B in both racemic form and as the (-)-enantiomer.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a7cae30bb042340672507a5ce5eca707 https://doi.org/10.1002/chin.201012180 Zobrazit plný text záznamu Plný text