Cyclic homopentapeptides 3. Synthetic modifications to the capreomycins and tuberactinomycins: Compounds with activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci
| Autor: | J. P. Rainville, Linde Robert Gerald, N. C. Birsner, Wei-Guo Su, David A. Whipple, R. J. Howe, C.P. MacLelland, Magee Thomas Victor, Joanna Clancy, Ramalakshmi Yegna Chandrasekaran, J.W. Petitpas, J.P. Lyssikatos, C.B. Vu |
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| Rok vydání: | 1997 |
| Předmět: |
Capreomycin
Chemistry Organic Chemistry Clinical Biochemistry Pharmaceutical Science Vancomycin-Resistant Enterococci medicine.disease_cause Biochemistry Combinatorial chemistry Methicillin-resistant Staphylococcus aureus Microbiology Tuberactinomycin Drug Discovery medicine Molecular Medicine Potency Cyclic pentapeptide Molecular Biology medicine.drug |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 7:1149-1152 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(97)00188-1 |
| Popis: | Modification and replacement of the β-lysine side chain of capreomycin and tuberactinomycin cyclic pentapeptide derivatives resulted in compounds with good antibacterial potency against multidrug-resistant pathogens. |
| Databáze: | OpenAIRE |
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