Effects of estazolam and triazolam on transient insomnia associated with phase-shifted sleep

Autor:	Mark J. Muehlbach, Thomas Roth, D. D. Morris, Paula K. Schweitzer, Timothy Roehrs, Gail Koshorek, James K. Walsh
Rok vydání:	1991
Předmět:	Triazolam business.industry Placebo Transient insomnia Sleep in non-human animals Estazolam Psychiatry and Mental health Alertness Neurology Phase shifted Anesthesia Medicine Pharmacology (medical) Neurology (clinical) Circadian rhythm business medicine.drug
Zdroj:	Human Psychopharmacology: Clinical and Experimental. 6:99-107
ISSN:	1099-1077 0885-6222
Popis:	Forty-eight healthy volunteers with a normal sleep/wake history participated in a two-centre, double-blind, parallel group study comparing the effects of estazolam 2.0 mg, triazolam 0.25 mg, and placebo on sleep, performance and alertness following 180 degree reversal in sleep/wake schedule. Sleep-phase reversal produced decreased sleep time, primarily during the last 2 hours of the sleep period. Estazolam prevented this transient insomnia by maintaining sleep in the latter part of the sleep period. Triazolam did not significantly change total sleep time, which was intermediate between that of the estazolam and placebo groups. Neither active compound produced significant effects on subsequent performance or alertness.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a7b85d860323429f973a97c2094c741d https://doi.org/10.1002/hup.470060204 Zobrazit plný text záznamu Plný text ve formátu PDF