| Autor: |
Harold G. Haines, Stanley A. Gall |
| Rok vydání: |
1974 |
| Předmět: |
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| Zdroj: |
Gynecologic Oncology. 2:451-459 |
| ISSN: |
0090-8258 |
| Popis: |
Two antigens associated with invasive squamous cell carcinoma of the cervix have been demonstrated by immunological techniques. All tumors tested contained one antigen which appeared to be specific for cervical carcinoma. A second antigen which cross-reacted with ovarian and vulvar carcinoma was found in 80% of the tumors tested. Cervical carcinoma antigen (CCA) and its antibody were tested for cross-reactivity with Herpes Virus Simplex Type-1 and Type-2 and their antiserum utilizing immuno-diffusion, counter-immunoelectrophoresis and immuno-fluorescent techniques. CCA prepared by either saline or perchloric acid extraction from cervical carcinoma showed a line of identity with a Herpes Virus Simplex Type-2 antigen when reacted against anti-HSV-2. Extracts of normal cervical tissue, breast and ovarian tissue as well as extracts of breast and colon cancer did not form precipitin lines. However, anti-CCA did not show a precipitin reaction when reacted with HSV-2 preparations. The significance of the findings lies in the demonstration that a HSV-2 induced antigen has been shown to be immunologically identical to associated tumor antigen extracted from cervical carcinomas. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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