QSAR Study of ortho-phenylphenol leukotriene B4 receptor antagonists
| Autor: | Michael J. Sofia, Kerry G. Bemis, James H. Wikel, David L. Saussy |
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| Rok vydání: | 1994 |
| Předmět: |
Quantitative structure–activity relationship
Leukotriene B4 Stereochemistry medicine.drug_class Organic Chemistry Clinical Biochemistry Leukotriene B4 receptor Substituent Antagonist Pharmaceutical Science Biological activity Receptor antagonist Biochemistry Predictive value chemistry.chemical_compound chemistry Drug Discovery medicine Molecular Medicine Molecular Biology |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 4:795-800 |
| ISSN: | 0960-894X |
| Popis: | QSAR models for a series of o-phenylphenol LTB 4 receptor antagonist have been developed with regression analysis. These models related specific features, electronic, size and shape, of the substituent with biological activity. The models have predictive value and may be useful in assisting future synthetic direction within this series of compounds. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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