Effects of Renal Sympathetic Denervation on the Atrial Electrophysiology in Dogs with Pacing-Induced Heart Failure

Autor: Hongping Deng, Qingyan Zhao, Zongwen Guo, Xiaozhan Wang, Jinping Xiao, Zixuan Dai, Peixing Wan, Xule Wang, Congxin Huang
Rok vydání: 2014
Předmět:
Zdroj: Pacing and Clinical Electrophysiology. 37:1357-1366
ISSN: 0147-8389
Popis: Background Heart failure (HF) and atrial fibrillation (AF) are associated with sympathetic activation. Renal sympathetic denervation (RSD) can suppress AF vulnerability. The impact of RSD on atrial electrophysiology in experimental HF is unclear. Methods Twenty-two beagles were randomized into control, HF, and HF + RSD groups. Control dogs were implanted cardiac pacemakers without pacing. Dogs in the HF group underwent right ventricular pacing for 3 weeks at 240 beats/min to induce HF. The dogs in the HF + RSD group received RSD and underwent the same HF-inducing procedure. Results The P-wave dispersion was higher in HF dogs than in the control and HF + RSD dogs (19 ± 3.1 ms vs 13 ± 2.3 ms, 15 ± 2.9 ms, P = 0.04). Conduction time within the interatrium was significantly longer in the HF dogs than that in the control and HF + RSD dogs (39 ± 4 ms vs 31 ± 3 ms, 33 ± 4 ms; P = 0.03). Window of vulnerability (WOV) of AF was widened in the HF dogs than in the HF + RSD dogs (37 ± 5 ms vs 14 ± 3 ms; P < 0.01), while AF could not be induced (WOV = 0) in the control dogs during S1S2 stimulation. The voltage in the threshold for AF inducibility was lower during ganglionated plexi stimulation in the HF dogs than in the control and HF + RSD dogs (1.8 ± 0.6 V vs 2.5 ± 0.6 V, 2.4 ± 0.4 V; P = 0.04). Conclusions RSD could reverse the atrial electrical remodeling and decrease AF inducibility in dogs with pacing-induced HF.
Databáze: OpenAIRE
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