Microfluidic chips for the study of cell migration under the effect of chemicals

Autor:	Anton Bukatin, Yu. A. Negulyaev, V. I. Chubinskiy-Nadezhdin, I. V. Kukhtevich, K. I. Belousov, V. Yu. Vasileva, Anatoly Evstrapov
Rok vydání:	2016
Předmět:	0301 basic medicine Centrifugal force 03 medical and health sciences 030104 developmental biology Materials science Physics and Astronomy (miscellaneous) Microfluidics Nanotechnology Cell migration Reaction chamber Chip
Zdroj:	Technical Physics Letters. 42:478-481
ISSN:	1090-6533 1063-7850
DOI:	10.1134/s1063785016050102
Popis:	Numerical simulation of the formation of a chemoattractant gradient in reaction chambers of a chip having different geometries enabled the determination of a structure suitable for the study of cell migration, in accordance with which hybrid polymer–glass microfluidic devices were manufactured. Verification of the procedures of alignment of cells in the reaction chamber of the chip by centrifugal force and subsequent culturing of the cells showed that microfluidic chips can be used to study cell migration under the effect of the chemoattractant gradient in vitro.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a79ec774bfbe65c76c0355be660cf54b https://doi.org/10.1134/s1063785016050102 Zobrazit plný text záznamu Plný text ve formátu PDF