Interactions between islets and regulatory immune cells in health and type 1 diabetes
| Autor: | Sarah J. Colpitts, Matthew A Budd, Sarah Q. Crome, Megan K. Levings, Mahdis Monajemi, C. Bruce Verchere |
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| Rok vydání: | 2021 |
| Předmět: |
0303 health sciences
Type 1 diabetes Effector Endocrinology Diabetes and Metabolism Pancreatic islets Regeneration (biology) Innate lymphoid cell Context (language use) Biology medicine.disease 3. Good health 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Immune system Immunity Immunology Internal Medicine medicine 030217 neurology & neurosurgery 030304 developmental biology |
| Zdroj: | Diabetologia. 64:2378-2388 |
| ISSN: | 1432-0428 0012-186X |
| Popis: | Type 1 diabetes results from defects in immune self-tolerance that lead to inflammatory infiltrate in pancreatic islets, beta cell dysfunction and T cell-mediated killing of beta cells. Although therapies that broadly inhibit immunity show promise to mitigate autoinflammatory damage caused by effector T cells, these are unlikely to permanently reset tolerance or promote regeneration of the already diminished pool of beta cells. An emerging concept is that certain populations of immune cells may have the capacity to both promote tolerance and support the restoration of beta cells by supporting proliferation, differentiation and/or regeneration. Here we will highlight three immune cell types-macrophages, regulatory T cells and innate lymphoid cells-for which there is evidence of dual roles of immune regulation and tissue regeneration. We explore how findings in this area from other fields might be extrapolated to type 1 diabetes and highlight recent discoveries in the context of type 1 diabetes. We also discuss technological advances that are supporting this area of research and contextualise new therapeutic avenues to consider for type 1 diabetes. |
| Databáze: | OpenAIRE |
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