| Autor: |
Daniel Junker, Matthias Becker, Teresa R. Wagner, Philipp D. Kaiser, Sandra Maier, Tanja M. Grimm, Johanna Griesbaum, Patrick Marsall, Jens Gruber, Bjoern Traenkle, Constanze Heinzel, Yudi T. Pinilla, Jana Held, Rolf Fendel, Andrea Kreidenweiss, Annika Nelde, Yacine Maringer, Sarah Schroeder, Juliane S. Walz, Karina Althaus, Gunalp Uzun, Marco Mikus, Tamam Bakchoul, Katja Schenke-Layland, Stefanie Bunk, Helene Haeberle, Siri Göpel, Michael Bitzer, Hanna Renk, Jonathan Remppis, Corinna Engel, Axel R. Franz, Manuela Harries, Barbora Kessel, Monika Strengert, Gerard Krause, Anne Zeck, Ulrich Rothbauer, Alex Dulovic, Nicole Schneiderhan-Marra |
| Rok vydání: |
2022 |
| Popis: |
The rapid emergence of the Omicron variant and its large number of mutations has led to its classification as a variant of concern (VOC) by the WHO(1). Initial studies on the neutralizing response towards this variant within convalescent and vaccinated individuals have identified substantial reductions(2-8). However many of these sample sets used in these studies were either small, uniform in nature, or were compared only to wild-type (WT) or, at most, a few other VOC. Here, we assessed IgG binding, (Angiotensin-Converting Enzyme 2) ACE2 binding inhibition, and antibody binding dynamics for the omicron variant compared to all other VOC and variants of interest (VOI)(9), in a large cohort of infected, vaccinated, and infected and then vaccinated individuals. While omicron was capable of binding to ACE2 efficiently, antibodies elicited by infection or immunization showed reduced IgG binding and ACE2 binding inhibition compared to WT and all VOC. Among vaccinated samples, antibody binding responses towards omicron were only improved following administration of a third dose. Overall, our results identify that omicron can still bind ACE2 while pre-existing antibodies can bind omicron. The extent of the mutations appear to inhibit the development of a neutralizing response, and as a result, omicron remains capable of evading immune control. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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