Identification of Anti-Inflammatory Constituents from Vietnamese Piper hymenophyllum
| Autor: | Phi Hung Nguyen, Huu Tung Nguyen, Manh Hung Tran, Dao Cuong To, Nhu Tuan Huynh, Viet Dung Hoang, Byung Sun Min |
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| Rok vydání: | 2020 |
| Předmět: |
biology
010405 organic chemistry Chemistry Stereochemistry medicine.drug_class Alkaloid Piperaceae biology.organism_classification 01 natural sciences In vitro Anti-inflammatory 0104 chemical sciences Nitric oxide Nitric oxide synthase 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Piper hymenophyllum Ic50 values biology.protein medicine General Pharmacology Toxicology and Pharmaceutics |
| Zdroj: | Revista Brasileira de Farmacognosia. 30:312-316 |
| ISSN: | 1981-528X |
| DOI: | 10.1007/s43450-020-00035-3 |
| Popis: | A new oxoaporphine alkaloid, (−)-(6aR,7R)-N-acetylnorushinsunine (1) together with eight known compounds (2–9) had been isolated from the aerial part of Vietnamese Piper hymenophyllum Miq., Piperaceae. The chemical structures of 1–9 were established mainly by spectroscopic, spectrometric, and chiroptical spectra. Their anti-inflammatory activity was evaluated against lipopolysaccharides-induced nitric oxide production in RAW264.7 cells in vitro. Among them, compounds 2–4 showed significant inhibitory activities against the lipopolysaccharide-induced nitric oxide production in RAW264.7 cells with IC50 values of 7.2, 9.3, and 4.5 μM, respectively. In addition, compounds 2 and 4 suppressed both lipopolysaccharides-induced cyclooxygenase-2 and inducible nitric oxide synthase expressions. These results proposed that Piper hymenophyllum and its constituents may exert anti-inflammatory effects. |
| Databáze: | OpenAIRE |
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