Triazole-Enabled Ruthenium(II) Carboxylate-Catalyzed C–H Arylation with Electron-Deficient Aryl Halides

Autor:	Diego Broggini, Torben Rogge, Thomas Müller, Lutz Ackermann, Xiaoyan Hou, Simon Wagschal, Hendrik Simon
Rok vydání:	2021
Předmět:	010405 organic chemistry Ligand Aryl Organic Chemistry Triazole chemistry.chemical_element 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences Catalysis Ruthenium chemistry.chemical_compound chemistry Carboxylate Selectivity Phosphine
Zdroj:	Synlett. 33:346-350
ISSN:	1437-2096 0936-5214
DOI:	10.1055/a-1495-6994
Popis:	A triazole-directed direct C–H arylation of arenes with electron-deficient aryl halides or a synthetically useful pyrimidyl chloride was achieved through ruthenium catalysis. Our novel strategy provides operationally simple and environmentally benign access to highly functionalized hetarenes, avoiding the use of strong organometallic bases. Detailed studies revealed a significant effect of the phosphine ligand, thereby permitting the reaction to occur with excellent levels of chemo- and position selectivity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a7737a0314bafae760aa545dad209de5 https://doi.org/10.1055/a-1495-6994 Zobrazit plný text záznamu