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Objective To analyze neonatal screening and recall of neonates suspected of having congenital metabolic disorders in Haidian District from 2010 to 2017 with the aim of improving the quality of neonatal screening. Methods We retrospectively analyzed data on neonates suspected of having congenital metabolic disorders on the basis of findings on neonatal screening in Haidian District from 2010 to 2017. Data on screening findings and recall of affected neonates were drawn from the neonatal screening bulletin in Beijing. The timing of the affected neonates recall was obtained from the Information Management System for Neonatal Disease Screening in Beijing. Results From 2010 to 2017, 336,202 neonates from 338,680 live births were screened for abnormalities in Haidian District, the average rate of screening being 99.27%. Of these, 3392 cases were found to have definite abnormalities, 3260(96.11%) of whom were recalled successfully for further testing to establish a diagnosis. Congenital metabolic disorders were diagnosed in 268 of the recalled neonates, 206 of them being found to have congenital hypothyroidism (CH), and 62 phenylketonuria (PKU). The prevalences of CH and PKU were 0.61‰, 0.18‰ respectively. The times toLevel-1 and Level-2 recall decreased over the study period from 28.83 days to 11.33 days and from 51.63 days to 41.92 days, respectively, these differences being statistically significant (P |
