A Rare, In-Frame BCR-ABL Fusion (e13a3) in a Patient with an Aggressive Chronic Myeloid Leukaemia

Autor:	Ivone B. Otazú, Augusto Pinto, María Belén Rivero, Ilana Zalcberg, Renata Olicio, Héctor N. Seuánez
Rok vydání:	2002
Předmět:	medicine.medical_specialty ABL Breakpoint breakpoint cluster region Cytogenetics Hematology General Medicine Gene rearrangement Biology Molecular biology Exon Real-time polymerase chain reaction hemic and lymphatic diseases Cancer research medicine neoplasms Gene
Zdroj:	Acta Haematologica. 108:150-153
ISSN:	1421-9662 0001-5792
DOI:	10.1159/000064701
Popis:	We have identified a rare BCR-ABL chimaeric gene with multiplex and nested RT-PCR in a patient with an unusually aggressive chronic myeloid leukaemia. cDNA sequencing showed an in-frame rearrangement with a breakpoint in BCR exon e13 (b2) and fusion with ABL exon 3 following skipping of the entire ABL exon a2. These data confirm the heterogeneity of breakpoints in BCR-ABL rearrangements.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a76c85ea7543e1f60b7cea6da1878e23 https://doi.org/10.1159/000064701 Zobrazit plný text záznamu