AN-nitrosochloroethyl-cephalosporin carbamate prodrug for antibody-directed enzyme prodrug therapy (ADEPT)

Autor:	Andrew J. Pratt, Rikki Peter Alexander, James A.E. Kraunsoe, Robert W. Bates
Rok vydání:	1996
Předmět:	biology medicine.drug_class Stereochemistry Chemistry Organic Chemistry Cephalosporin Substrate (chemistry) Adept Prodrug biology.organism_classification Biochemistry Acylation Drug Discovery Nitrosation polycyclic compounds medicine Enterobacter cloacae Conjugate
Zdroj:	Tetrahedron. 52:5983-5988
ISSN:	0040-4020
DOI:	10.1016/0040-4020(96)00228-1
Popis:	N-Nitrosochloroethyl-cephem7 was prepared via acylation and selective nitrosation of a cephalothin derivative. This cephalosporin is an efficient substrate for Enterobacter cloacae P99 β-lactamase. Kinetic parameters were determined for enzyme-catalysed hydrolysis. This cephalosporin is a potential prodrug for the delivery of bis-alkylating chloroethyldiazo species to tumours by antibody-β-lactamase conjugates. Download : Download full-size image
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a759b476dc553157e04449156e4a8445 https://doi.org/10.1016/0040-4020(96)00228-1 Zobrazit plný text záznamu Full Text from ScienceDirect