Reproductive function in persons who have been cured of cancer
Autor: | Tatiana F. Gavrilenko, Svetlana B. Polikarpova, Timur T. Valiev, Valerii E. Ponomarev |
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Rok vydání: | 2021 |
Předmět: | |
Zdroj: | Consilium Medicum. :533-538 |
ISSN: | 2542-2170 2075-1753 |
DOI: | 10.26442/20751753.2021.7.200843 |
Popis: | Modern cancer therapy programs allow an increasing number of patients to be cured, and therefore the quality of their subsequent life is an important task of clinical oncology. The ability to realize reproductive potential is one of the main criteria for the quality of life. Nevertheless, chemoradiation therapy used in the treatment of malignant tumors can cause temporary or permanent infertility. Currently, there are options to protect the reproductive system from chemoradiation treatment (administration of ethinylestradiol drugs, gonadotropin-releasing hormone agonists) or harvesting seminal fluid/oocytes, and cryopreservation of ovarian tissue. However, the low awareness of doctors about modern reproductive technologies in the treatment of persons cured from cancer leads to the fact that these methods are not used actively enough. The article presents the main chemotherapy drugs used in the treatment of malignant tumors that can cause an impairment of reproductive function; describes their pathological effects on oocytes and spermatozoa; provides methods of protecting the reproductive function in persons who take chemoradiation therapy or have completed antitumor therapy. |
Databáze: | OpenAIRE |
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