ChemInform Abstract: P4S10and Na2S-Mediated Novel Annulation Routes to C-Fused Thiophenes

Autor:	Nasima Yasmin, Munmun Ghosh, Jayanta K. Ray
Rok vydání:	2014
Předmět:	chemistry.chemical_compound Annulation Chemistry Yield (chemistry) Phosphorus pentasulfide General Medicine Benzene Thiophene derivatives Medicinal chemistry Sodium sulfide Tetrahydrofuran
Zdroj:	ChemInform. 45
ISSN:	0931-7597
DOI:	10.1002/chin.201452108
Popis:	Two efficient hetero-annulation protocols have been developed for the synthesis of stable substituted c-fused thiophene derivatives with moderate to high yield. 3-(2-formyl-phenyl)-acrylic acid esters afforded benzo[c]thiophenes in the presence of phosphorus pentasulfide in refluxing benzene while 3-(2-formyl-cycloalkenyl)α,β-unsaturated esters resulted in the formation of c-fused thiophene derivatives when reacted with sodium sulfide in refluxing tetrahydrofuran.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a756d0109785faf3b7d5a0f311505026 https://doi.org/10.1002/chin.201452108 Zobrazit plný text záznamu Plný text