Mast Cells as a Possible Source of Haemophilus influenzae-Induced Changes in Plasma and Lung Histamine Levels

Autor:	G. K. Terpstra, J. Kreukniet, Jan A. M. Raaijmakers
Rok vydání:	1980
Předmět:	Lung Immunology General Medicine Biology medicine.disease_cause Haemophilus influenzae Microbiology Vaccination chemistry.chemical_compound medicine.anatomical_structure chemistry medicine Immunology and Allergy Histidine decarboxylase activity Incubation Histamine
Zdroj:	International Archives of Allergy and Immunology. 61:352-357
ISSN:	1423-0097 1018-2438
DOI:	10.1159/000232459
Popis:	Histidine decarboxylase activity and histamine levels of peritoneal mast cells were enhanced 4 days after intraperitoneal Haemophilus influenzae vaccination of rats. Incubation of the cells with propranolol (3.4 × 10––4M) resulted in histamine release and an increased histidine decarboxylase activity. Histidine decarboxylase activity and histamine release were more increased in the presence of propranolol in mast cells obtained from H. influenzae-vaccinated rats. An increased mediator release is also suggested by the increase of the number of peritoneal eosinophils. These data might explain the earlier observed enhanced plasma and lung histamine levels in H. influenzae-vaccinated rats.
Databáze:	OpenAIRE
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