Rapid and accurate diagnosis of brain abscess caused by Nocardia asiatica with a combination of Ziehl‐Neelsen staining and metagenomics next‐generation sequencing
| Autor: | Yuanzhong Chen, Raoli He, Qinyong Ye, Xiaochun Chen, Tianzao Huang, Dianbo Qu, Jian Zhang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pathology
medicine.medical_specialty business.industry Mortality rate bacterial infections and mycoses medicine.disease Staining 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Neurology chemistry Infectious disease (medical specialty) Diabetes mellitus parasitic diseases Linezolid Medicine Ziehl–Neelsen stain 030212 general & internal medicine Neurology (clinical) business Pathological Brain abscess 030217 neurology & neurosurgery |
| Zdroj: | European Journal of Neurology. 28:355-357 |
| ISSN: | 1468-1331 1351-5101 |
| Popis: | Background and purpose Early and accurate diagnosis is vital in cerebral nocardiosis, a very rare and infectious disease associated with a high mortality rate. Herein, we report a case that a patient with brain abscess was swiftly diagnosed and successfully treated. Methods We report a case of a 61-year-old woman with a brain abscess caused by Nocardia asiatica, diagnosed by a combination of Ziehl-Neelsen staining and metagenomics next-generation sequencing (mNGS). Results A 61-year-old woman with left breast cancer resection, diabetes mellitus and a 7-month discontinuous cough and fever was admitted to our hospital. On the third day of hospitalization, she experienced a sudden loss of consciousness and was diagnosed with a brain abscess and a pathological change in cerebral mass on brain magnetic resonance imaging (MRI). Due to the failure of culturing any microorganisms from the pup, the dissected sample from the patient with Ziehl-Neelsen staining tested positive for acid-fast bacilli and was subjected to mNGS. The pathogen was identified as N. asiatica and the patient was treated accordingly with linezolid and trimethoprim-sulfamethoxazole until complete recovery was confirmed by the follow-up cerebral MRI. Conclusions This is the first case report of a brain abscess caused by N. asiatica being swiftly diagnosed by a combination of Ziehl-Neelsen staining and mNGS. This rapid diagnosis allowed us to successfully treat this rare infection. |
| Databáze: | OpenAIRE |
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