Synthesis, Crystal Structure and Inhibitory Activities of 2-(N-Tert-Butoxycarbonylamino)Pyridine Derivatives
| Autor: | Bao-Tong Li, Ming-Yu Zhao, Xu-Liang Nie, Xugen Shi, Yun-Lian Shi, Da-Yong Peng, Ming-Zhu Shi, Tao Huang, Xue-Xiang Ren |
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| Rok vydání: | 2020 |
| Předmět: |
Pyricularia
biology Chemistry Stereochemistry Biological activity General Chemistry Crystal structure Carbon-13 NMR 010402 general chemistry 010403 inorganic & nuclear chemistry Condensed Matter Physics Alternaria biology.organism_classification 01 natural sciences 0104 chemical sciences chemistry.chemical_compound Crystallography Pyridine Proton NMR Organometallic chemistry |
| Zdroj: | Journal of Chemical Crystallography. 51:155-160 |
| ISSN: | 1572-8854 1074-1542 |
| Popis: | 2-(N-tert-butoxycarbonylamino) pyridine and 2-(N-tert-butoxycarbonylamino)-3-methylpyridine were synthesized in a one-step method using either 2-aminopyridine or 2-amino-3-methyphyridine with tert-butylcarbonyl anhydride as the starting materials. The products were characterized by single-crystal X-ray diffraction, 1H NMR, 13C NMR, and HRMS. The biological activity of the two compounds against five fungi was determined. 2-(N-tert-butoxycarbonylamino) pyridine has more than 50% inhibitory activity against Pyricularia oryzae, Colletotrichum gloeosporioides, and Alternaria alternate. In addition, the inhibitory activity of 2-(N-tert-butoxycarbonylamino)-3-methylpyridine against Alternaria alternate reached 67.69%. Two 2-BOC aminopyridine derivatives were synthesized and structurally characterized by 1H NMR, 13C NMR, HRMS analysis and X-ray crystal diffraction. The inhibitory activity both compounds was studied. |
| Databáze: | OpenAIRE |
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