Effect of an arsenoso compound on experimental Trichinella spiralis in mice

Autor:	G. Soo-Hoo
Rok vydání:	1952
Předmět:	Fatal outcome biology Hydrochloride Inoculation Immunology Observation period Trichinella spiralis Trichinella General Medicine Trichinosis Pharmacology medicine.disease biology.organism_classification In vitro chemistry.chemical_compound Infectious Diseases chemistry medicine Parasitology
Zdroj:	Experimental Parasitology. 1:377-383
ISSN:	0014-4894
DOI:	10.1016/0014-4894(52)90027-1
Popis:	1. (1) Evidence is submitted that a new arsenoso compound (N-(p-arsenoso-benzyl)-glycine amide hydrochloride), if given once shortly after an oral inoculation of 2000 larvae of T. spiralis prevented fatal outcome in 64% of the animals over a 10 week's observation period. 2. (2) The active dose (500 mg/kg per os) was identical with the maximal tolerated dose; a smaller dose of 250 mg/kg caused only delay of death. Longer intervals between inoculation and treatment interfered similarly with the effectiveness of the drug. 3. (3) The arsenoso compound exerted an effect on Trichinella larvae exposed to it in vitro for at least 6 to 24 hours.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a737b84f6823ddf043de1961bbceb93c https://doi.org/10.1016/0014-4894(52)90027-1 Zobrazit plný text záznamu