ChemInform Abstract: Synthesis and Biological Activities of Optically Active 6-(3-(3,4- Dimethoxybenzylamino)-2-hydroxypropoxy)-2(1H)-quinolinone (OPC-18790)

Autor:	Kazumi Takemoto, Youichi Yabuuchi, Michiaki Tominaga, Toyoki Mori, Takafumi Fujioka, Sachiko Tsujimi, Tetsumi Hosokawa, Shuji Teramoto, Takumi Sumida
Rok vydání:	2010
Předmět:	chemistry.chemical_compound Chemistry Stereochemistry In vitro study Epichlorohydrin General Medicine Optically active Enantiomer Alkylation Ring (chemistry)
Zdroj:	ChemInform. 28
ISSN:	0931-7597
Popis:	The enantiomers of 6-[3-(3,4-dimethoxybenzylamino)-2-hydroxypropoxy]-2(1H)-quinolinon e (OPC-18790), a novel cardiotonic agent, were synthesized and evaluated for positive inotropic activity. The key intermediates, 2,3-epoxypropoxy derivatives, were obtained by the alkylation of 6-hydroxy-2(1H)-quinolinone with optically active epichlorohydrin and subsequent ring closure. In an in vitro study, the (R)-(+)-isomer was about 10-fold more potent than the (S)-(-)-isomer.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a7379e7b3529c801df5f8765f9b59276 https://doi.org/10.1002/chin.199711118 Zobrazit plný text záznamu Plný text