'Chemotherapy-periodized' Exercise to Accommodate for Cyclical Variation in Fatigue
| Autor: | Tamara Shenkier, Kelcey A. Bland, David S. Zucker, Kristin L. Campbell, Amy A. Kirkham, Karen A. Gelmon, Joshua M. Bovard, Margot K. Davis, Donald C. McKenzie |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
education.field_of_study
medicine.medical_specialty Chemotherapy Taxane business.industry medicine.medical_treatment Population Resistance training Physical Therapy Sports Therapy and Rehabilitation 030229 sport sciences medicine.disease 03 medical and health sciences 0302 clinical medicine Breast cancer Standard error Internal medicine Medicine Orthopedics and Sports Medicine Medical prescription business education Exercise prescription |
| Zdroj: | Medicine & Science in Sports & Exercise. 52:278-286 |
| ISSN: | 1530-0315 0195-9131 |
| DOI: | 10.1249/mss.0000000000002151 |
| Popis: | PURPOSE The purpose of this study was to provide a rationale for "chemotherapy-periodized" exercise by characterizing cyclical variations in fatigue and exercise response across a chemotherapy cycle and comparing exercise adherence during chemotherapy between a prescription that is periodized according to chemotherapy cycle length and a standard linearly progressed prescription. METHODS Women with breast cancer who were prescribed taxane-based chemotherapy were randomly assigned to a supervised aerobic and resistance exercise program after a chemotherapy-periodized exercise prescription (n = 12) or to usual care during chemotherapy (n = 15). Fatigue and steady state exercise responses were assessed in both groups before the first taxane treatment and across the third treatment (i.e., 0-3 d prior and 3-5 d after the third treatment, and 0-3 d before the fourth treatment) to assess cyclical variations. Adherence to the chemotherapy-periodized exercise prescription was compared with adherence to a standard linear prescription from a prior study in a similar population (n = 51). RESULTS Fatigue increased from baseline (marginal mean ± standard error: 3.2 ± 0.4) to before the third treatment (4.1 ± 0.4, P = 0.025), then peaked at 3 to 5 d after the third treatment (5.1 ± 0.4, P = 0.001), before recovering before the fourth treatment (4.3 ± 0.5, P = 0.021). The peak in fatigue at 3 to 5 d post-third treatment corresponded to a decrease in steady state exercise oxygen consumption (V˙O2) (P = 0.013). Compared with a standard linear exercise prescription during chemotherapy, a chemotherapy-periodized exercise prescription resulted in higher attendance during the week after chemotherapy (57% ± 30% vs 77% ± 28%, P = 0.04) and overall attendance (63% + 25% vs 78% ± 23%, P = 0.05). CONCLUSIONS Fatigue and exercise V˙O2 vary across a chemotherapy cycle. A chemotherapy-periodized exercise prescription that accommodates cyclical variations in fatigue may increase adherence to supervised exercise. |
| Databáze: | OpenAIRE |
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