Vitamin D receptor polymorphisms and the polycystic ovary syndrome: A systematic review
| Autor: | Michelle Teodoro Alves, Cláudia N. Ferreira, Karina Braga Gomes, Guilherme Victor Oliveira Pimenta dos Reis, Natália Alves Gontijo, Kathryna Fontana Rodrigues |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
030219 obstetrics & reproductive medicine endocrine system diseases biology business.industry Hyperandrogenism Obstetrics and Gynecology 030209 endocrinology & metabolism medicine.disease Polycystic ovary Calcitriol receptor Obesity 03 medical and health sciences 0302 clinical medicine Sex hormone-binding globulin Endocrinology Insulin resistance Internal medicine biology.protein Etiology Vitamin D and neurology Medicine business |
| Zdroj: | Journal of Obstetrics and Gynaecology Research. 43:436-446 |
| ISSN: | 1341-8076 |
| Popis: | Polycystic ovary syndrome (PCOS) is the most frequent endocrinological disorder that affects women of reproductive age, leading to metabolic alterations, such as hyperandrogenism, obesity, menstrual irregularities, insulin resistance, and polycystic ovaries. The etiology remains unclear, but several genetic and environmental factors have been correlated with manifestations of this syndrome. Vitamin D plays important roles in metabolic pathways affected by PCOS, including calcium homeostasis, the insulin pathway, and sex hormone synthesis. Vitamin D concentration has been related with the severity of this disorder, and vitamin D receptor polymorphisms have been shown in some studies to have an association with some of the patterns presented by PCOS. The objective of this study is to provide an up-to-date review about vitamin D receptor polymorphisms and their association with PCOS. |
| Databáze: | OpenAIRE |
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