Using information from both parents when testing for association between marker and disease loci

Autor:	R. N. Curnow, John C. Whittaker, A. P. Morris
Rok vydání:	1998
Předmět:	Genetics Linkage (software) Epidemiology Parenteral transmission Disequilibrium Disease Biology Gene mapping Genetic marker medicine Allele medicine.symptom Association (psychology) Genetics (clinical)
Zdroj:	Genetic Epidemiology. 15:193-200
ISSN:	1098-2272 0741-0395
DOI:	10.1002/(sici)1098-2272(1998)15:2<193::aid-gepi7>3.0.co;2-7
Popis:	Several extensions of the transmission/disequilibrium test (TDT) to multi-allelic markers now exist. In some of these, however, separate tests must be performed on male and female parents because of the non-independence of parental transmission patterns, reducing power, and complicating interpretation of the test results. Here we show that this non-independence is asymptotically irrelevant when using the allelic TDT of Bickeboller and Clerget-Darpoux [(1995) Genet Epidemiol 12:577-582], allowing the analysis of data from both parents simultaneously.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a727e59c0bd361d1b4f4ac66aa2de77a https://doi.org/10.1002/(sici)1098-2272(1998)15:2<193::aid-gepi7>3.0.co Zobrazit plný text záznamu Plný text