Marine natural products. VII. Bioactive triterpene-oligoglycosides from the sea cucumber Holothuria leucospilota Brandt (1). Structure of holothurin B
Autor: | Isao Kitagawa, Takao Matsuno, Yoshimasa Kyogoku, Hideo Akutsu, Takao Nishino, Motomasa Kobayashi |
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Rok vydání: | 1981 |
Předmět: | |
Zdroj: | Chemical and Pharmaceutical Bulletin. 29:1942-1950 |
ISSN: | 1347-5223 0009-2363 |
DOI: | 10.1248/cpb.29.1942 |
Popis: | Two lanostane-type triterpene oligoglycosides designated as holothurin A and holothurin B were isolated from the sea cucumber Holothuria leucospilota BRANDT (=H. vagabnda SELENKA). The chemical structure of holothurin B, which is contained mainly in the body walls, has been established as 3-O-(2'-O-β-D-quinovopyranosyl-β-D-xylopyranosyl)-holothurigenol 4'-O-sodium sulfate (6), on the basis of chemical, physicochemical, and biochemical evidence. The genuine aglycone of holothurin B was designated as holothurigenol (2) and the C-20 and C-22 configurations of 2 and the artifact aglycone 22, 25-oxidoholothurinogenin (1) have been elucidated as S. |
Databáze: | OpenAIRE |
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