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Some Nigerian plants used in traditional medicine to treat tuberculosis and/or some of its symptoms were screened for in vitro activity against Mycobacterium smegmatis and a clinical isolate of Mycobacterium tuberculosis . Only 3 of the 6 crude methanolic extracts of the 6 plant species exhibited inhibitory activities against M. smegmatis , while 5 inhibited the growth of M. tuberculosis . Three and four water extracts inhibited M. smegmatis and M. tuberculosis , respectively. Both methanol and water extracts of Artemisia annua, Pterocarpus erinaceus and Piper guiniense showed inhibitory activities against the two Mycobacteria . Methanol extracts of Anogeissus leiocarpus and Piper guiniense exhibited the highest activity against M. tuberculosis with a minimum inhibitory concentration of 0.1 mg/ml. Key Words: Nigerian medicinal plants, Mycobacterium species, Inhibition East & Central African Journal of Pharmaceutical Sciences Vol.6(1) 2003: 15-19 |
