Risk Factors for Mortality in Pneumocystis jirovecii Pneumonia in Patients with Inflammatory Bowel Disease
| Autor: | Akira Matsui, Teppei Omori, Katsuya Endo, Hiroki Tanaka, Shinichiro Shinzaki, Atsushi Yoshida, Shuji Kanmura, Tetsu Kinjo, Norimasa Fukata, Makoto Ooi, Ryohei Hayashi, Taku Kobayashi, Ryosuke Sakemi, Yoko Yokoyama, Toshio Morizane, Takuya Yoshino, Akihiro Yamada, Shigeki Bamba, Sakuma Takahashi, Noriko Kamata, Shinya Ashizuka, Toshimitsu Fujii, Noriyuki Ogata |
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| Rok vydání: | 2018 |
| Předmět: |
Crohn's disease
medicine.medical_specialty medicine.diagnostic_test business.industry Mortality rate Gastroenterology Retrospective cohort study medicine.disease Inflammatory bowel disease Ulcerative colitis chemistry.chemical_compound chemistry Internal medicine Medicine Blood test Risk factor business Sulfamethoxazole/Trimethoprim |
| Zdroj: | Inflammatory Intestinal Diseases. 3:167-172 |
| ISSN: | 2296-9365 2296-9403 |
| Popis: | Background: Pneumocystis jirovecii pneumonia (PJP) is highly fatal once infection is established. In this study, we investigated the risk of PJP mortality in patients with inflammatory bowel disease (IBD). Methods: We conducted a retrospective observational study of case data from IBD patients who developed PJP, compiled from 17 collaborating institutions. Parameters such as age, sex, medications used, and blood test results were analyzed to identify risk factors for mortality. Results: The mortality rate among the 28 IBD patients who developed PJP was 17.9%. A low serum albumin level at the start of IBD treatment was identified as a risk factor for mortality and showed the following association with probability of death (P): P = 1/[1 + exp(–5.5 + 2.4 × Alb). The probability of death exceeded 0.5 when serum albumin was 2.2 g/dL or lower. Conclusion: Patients with IBD who develop PJP have a high mortality rate and often cannot continue treatment with medication alone. Therefore, it is necessary to pay attention to albumin levels at the start of immunosuppressive therapy when creating a treatment plan. |
| Databáze: | OpenAIRE |
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