68Ga-PSMA-11 PET/CT-derived metabolic parameters for determination of whole-body tumor burden and treatment response in prostate cancer

Autor: Tobias Bäuerle, Michael Cordes, Alexander Cavallaro, Michael Beck, Philipp Ritt, Daniela Schmidt, Michael Uder, Olaf Prante, Peter J. Goebell, Christian Schmidkonz, Torsten Kuwert, Bernd Wullich, Theresa Ida Goetz
Rok vydání: 2018
Předmět:
Zdroj: European Journal of Nuclear Medicine and Molecular Imaging. 45:1862-1872
ISSN: 1619-7089
1619-7070
DOI: 10.1007/s00259-018-4042-z
Popis: We aimed at evaluating the role of 68Ga-PSMA-11 PET/CT-derived metabolic parameters for assessment of whole-body tumor burden and its capability to determine therapeutic response in patients with prostate cancer. A total of 142 patients with biochemical recurrence of prostate cancer underwent PET/CT with [68Ga]Ga-PSMA-HBED-CC (68Ga-PSMA-11). Quantitative assessment of all 641 68Ga-PSMA-11-positive lesions in the field of view was performed to calculate PSMA-derived parameters, including whole-body PSMA tumor volume (PSMA-TV) and whole-body total lesion PSMA (TL-PSMA), as well as the established SUVmax and SUVmean values. All PET-derived parameters were tested for correlation with serum PSA levels and for association with Gleason scores. In 23 patients who underwent 68Ga-PSMA-11 PET/CT before and after therapy with either external beam radiation, androgen deprivation, or docetaxel chemotherapy, SUVmax and TL-PSMA were compared to radiographic response assessment of CT images based on RECIST 1.1 criteria and to biochemical response determined by changes of serum PSA levels. PSMA-TV and TL-PSMA demonstrated a significant correlation with serum PSA levels (P
Databáze: OpenAIRE
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