Synthesis of 25X-BOMes and 25X-NBOHs (X = H, I, Br) for pharmacological studies and as reference standards for forensic purposes

Autor:	Ângelo de Fátima, Graziele Martins Borges, Felipe T. Martins, Marcelo Pereira Queiroz, Leonardo da Silva Neto, Wellington Alves de Barros
Rok vydání:	2021
Předmět:	010405 organic chemistry Chemistry Organic Chemistry 010402 general chemistry 01 natural sciences Biochemistry 0104 chemical sciences Forensic science chemistry.chemical_compound Salicylaldehyde Yield (chemistry) Drug Discovery Organic chemistry Reference standards
Zdroj:	Tetrahedron Letters. 66:152804
ISSN:	0040-4039
Popis:	An expeditious method is reported for the synthesis of three NBOHs (25H-, 25I- and 25B-NBOH; 9–38% overall yield) and three NBOMes (25H-, 25I- and 25B-NBOMe; 7–33% overall yield) from salicylaldehyde and 2-methoxyaldehyde, respectively. The X-ray structures of 25H-, 25I- and 25B-NBOH.HCl were also determined. Our approach should provide a general entry for preparing such a class of substances for pharmacological and forensic purposes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a7185349824319af338488a2a2c29c5c https://doi.org/10.1016/j.tetlet.2020.152804 Zobrazit plný text záznamu Full Text from ScienceDirect