Sensitive Period for Rubratoxin 6-Induced Malformations in ICR Mice
| Autor: | Sri Sudarwati, Kenji Okada, Tien Wiati Surjono, Tjitjih Syarief |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities Embryology Omphalocele Anophthalmia Appendicular skeleton business.industry General Medicine Anatomy medicine.disease Renal hypoplasia Microphthalmia Rubratoxin B Hypoplasia chemistry.chemical_compound medicine.anatomical_structure Rubratoxin chemistry Pediatrics Perinatology and Child Health medicine business Developmental Biology |
| Zdroj: | Congenital Anomalies. 25:297-304 |
| ISSN: | 1741-4520 0914-3505 |
| DOI: | 10.1111/j.1741-4520.1985.tb00640.x |
| Popis: | Single dose of 0.6 or 1.2 mg/kg of rubratoxin B was administered intraperitoneally into the pregnant S1c: ICR mice on one day between day 6 and day 9 of gestation, and the fetuses were examined on day 18 of gestation. Gross malformations produced were neural tube defects, omphalocele, cleft palate, short or kinky tail, clubfoot and micromelia. Razor blade sections revealed dysgenetic hydrocephaly, microphthalmia, anophthalmia, renal hypoplasia, unilateral absence of kidney and uterine horn hypoplasia, ventricular septal defect (VSD) and apex bifida of the heart. Skeletal specimens showed dislocation, deformity, fusion, splitting or absence of vertebral bodies, fusion of vertebral arches, fused ribs, and scoliosis. Delayed ossification of axial and appendicular skeleton was also noted. The sensitive periods for the above rubratoxin B-induced malformations were restricted in the beginning of organogenetic period. No rubratoxin B-specific type of malformations was found. |
| Databáze: | OpenAIRE |
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