Evaluation of compatibility between dried extracts of Myracrodruon urundeuva Allemão and pharmaceutical excipients by TG and DTA

Autor: Valmir Gomes de Souza, Islaine de Souza Salvador, Ionaldo José Lima Diniz Basílio, Antonio João de Lima Neto, Fábio Santos de Souza, Rui Oliveira Macêdo, Agna Hélia de Oliveira, Cícero Flávio Soares Aragão, Renata Da Silva Leite
Rok vydání: 2017
Předmět:
Zdroj: Journal of Thermal Analysis and Calorimetry. 133:633-639
ISSN: 1588-2926
1388-6150
Popis: Thermoanalytical techniques have been applied in studies of herbal products. Myracrodruon urundeuva Allemao (Anacardiaceae) is a native of Brazil with medicinal properties. This study aimed to characterize the dry extracts of M. urundeuva Allemao and to assess the compatibility of extracts with pharmaceutical excipients in physical mixtures using thermogravimetry (TG) and differential thermal analysis (DTA). The TG curve of M. urundeuva dry extract (ES) showed the occurrence of four mass loss events. The most significant mass loss of extract was observed between 193.5 and 267.0 °C with a loss of 29.7%. The DTA curve showed the endothermic nature of this event with a peak at 235.8 °C (ΔH = 568.5 J g−1). This event is associated with the thermal decomposition of carbohydrates and other organic compounds present in the plant. The SEM image showed the particles of dry extract with spherical shapes, irregular sizes and rough surfaces. SEM analysis of physical mixtures showed that extract dry particles maintained their spherical morphology and appeared uniformly dispersed in the excipient particles. The TG and DTA curves showed no thermal incompatibility between the ES and the excipients lactose, cellulose and starch, but indicated a possible interaction with maltodextrin.
Databáze: OpenAIRE
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