Sialyltransferase Activity in Human Cells Infected with Human Immunodeficiency Virus—1 (HIV-1) in Cell Culture

Autor:	L. Froloshka, S. Ivanov, Radka Argirova, R. Gavazova, D. Dundarova, Dimitar Ivanov, Z. Mladenova, S. Raleva
Rok vydání:	2005
Předmět:	chemistry.chemical_classification Human immunodeficiency virus (HIV) Time data Biology medicine.disease_cause Virology Virus Sialyltransferase activity carbohydrates (lipids) chemistry.chemical_compound Enzyme Glycolipid chemistry Biosynthesis medicine Glycoprotein Biotechnology
Zdroj:	Biotechnology & Biotechnological Equipment. 19:72-77
ISSN:	1314-3530 1310-2818
DOI:	10.1080/13102818.2005.10817266
Popis:	es (ST) are a family of enzymes specifically transporting sialic acids (SAs) onto nascent glycoproteins and glycolipids, so participating in glycoprotein synthesis. The envelope of human immunodeficiency virus - type 1 (HIV-1) is highly glycosylated and sialylated. Here we report for the first time data on ST-activity in acutely and chronically HIV-1 infected cells in cell culture. The results demonstrated higher ST activity in cytosols of both acutely and chronically infected cells compared to uninfected ones. Data fit well to our earlier assumption about the virus specific character of sialylation, found by using of direct radioactive precursor of biosynthesis of SAs as terminal moieties of sialoglycopro- teins (Sgps) of HIV-1 in cell culture.
Databáze:	OpenAIRE
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