Formation of (S)-5-Cyclohexyl-5-phenyl-1,3-dioxolane-2,4-dione: A Key Intermediate in the Synthesis of (S)-Oxybutynin Hydrochloride

Autor:	Thomas R. Wagler, Surendra P. Singh, Philomen de Croos, Roger P. Bakale, Charles P. Vandenbossche
Rok vydání:	2010
Předmět:	chemistry.chemical_compound Drug candidate Chemistry Hydrochloride Dioxolane Organic Chemistry Organic chemistry Oxybutynin hydrochloride Physical and Theoretical Chemistry
Zdroj:	Organic Process Research & Development. 14:921-925
ISSN:	1520-586X 1083-6160
DOI:	10.1021/op100021w
Popis:	The synthesis of the drug candidate (S)-oxybutynin hydrochloride 1 is described. The procedure involves initial activation of (S)-cyclohexylmandelic acid 2, using isobutylchloroformate, followed by...
Databáze:	OpenAIRE
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