Pain during topical photodynamic therapy - comparing methyl aminolevulinate (Metvix®) to aminolaevulinic acid (Ameluz®); an intra-individual clinical study
| Autor: | Kian Zarchi, Shiva Yazdanyar, Gregor B.E. Jemec |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Side effect business.industry Visual analogue scale medicine.medical_treatment Actinic keratosis Biophysics Aminolaevulinic acid Photodynamic therapy Dermatology medicine.disease 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Oncology Methyl aminolevulinate 030220 oncology & carcinogenesis Scalp medicine Forehead Pharmacology (medical) business medicine.drug |
| Zdroj: | Photodiagnosis and Photodynamic Therapy. 20:6-9 |
| ISSN: | 1572-1000 |
| DOI: | 10.1016/j.pdpdt.2017.07.010 |
| Popis: | Background Actinic keratoses are often treated by photodynamic therapy. However, the main side effect of this treatment is pain during and shortly after illumination. Objectives To evaluate, in an intra-individual study, whether the pain response differ in treatment of actinic keratoses in scalp and forhead, using branded methyl aminolevulinate (MAL) and aminolaevulinic acid (ALA). Materials and methods Patients with mild to moderate actinic keratoses on forehead and scalp were treated with methyl aminolaevulinate (MAL)-PDT and aminolaevulinic acid (ALA)-PDT on two similar areas of forehead and scalp. The pain response were measured using visual analogue scale ranging from 0 to 10 during the illumination and 30 min after the treatment. Results Fourteen patients completed treatment to MAL and ALA-PDT. We found no significant difference in pain intensity between MAL and ALA-PDT, neither during the treatment (p-value = 1) nor 30 min after the treatment (p-value of 0.19). Conclusions This intra-individual study demonstrate no significant difference between the pain response during PDT using methyl aminolevulinate and aminolaevulinic acid. |
| Databáze: | OpenAIRE |
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